System In Vivo A Mucosal IgA-Mediated Excretory Immune
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منابع مشابه
A mucosal IgA-mediated excretory immune system in vivo.
The capacity of mucosal IgA Abs to serve as an excretory immune system in vivo was investigated. Mice expressing a transgenic TCR were immunized intragastrically with the cognate Ag to elicit a vigorous mucosal IgA Ab response. Soon after i.v. challenge, Ag was detected within the epithelial cells of the small intestinal crypts and to a lesser degree within the epithelial cells higher up the vi...
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Lamm, Michael E. Current Concepts in Mucosal Immunity. IV. How epithelial transport of IgA antibodies relates to host defense. Am. J. Physiol. 274 (Gastrointest. Liver Physiol. 37): G614–G617, 1998.—The humoral arm of the mucosal immune system is principally composed of locally synthesized polymeric IgA, whose Fc portion is adapted for binding to the polymeric immunoglobulin receptor that is ex...
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The humoral arm of the mucosal immune system is principally composed of locally synthesized polymeric IgA, whose Fc portion is adapted for binding to the polymeric immunoglobulin receptor that is expressed on the basolateral surface of mucosal epithelial cells, including enterocytes. This receptor mediates the endocytosis and transcytosis of polymeric IgA, which allows IgA to function in host d...
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تاریخ انتشار 2001